Health Implications of Perchlorate Ingestion e-bog
403,64 DKK
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Perchlorate"e;a powerful oxidant used in solid rocket fuels by the military and aerospace industry"e;has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for no...
E-bog
403,64 DKK
Forlag
National Academies Press
Udgivet
18 april 2005
Længde
276 sider
Genrer
Public health and preventive medicine
Sprog
English
Format
pdf
Beskyttelse
LCP
ISBN
9780309548113
Perchlorate"e;a powerful oxidant used in solid rocket fuels by the military and aerospace industry"e;has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA).The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPAs basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weight"e;an amount more than 20 times the reference dose proposed by EPA"e;should not threaten the health of even the most sensitive populations.