hERG Cardiac Potassium Channel (e-bog) af -
Goode, Jamie A. (redaktør)

hERG Cardiac Potassium Channel e-bog

1459,97 DKK (inkl. moms 1824,96 DKK)
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties...
E-bog 1459,97 DKK
Forfattere Goode, Jamie A. (redaktør)
Forlag Wiley
Udgivet 14 juni 2005
Genrer Physiology
Sprog English
Format pdf
Beskyttelse LCP
ISBN 9780470021415
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.