Structural and Evolutionary Genomics e-bog
619,55 DKK
(inkl. moms 774,44 DKK)
Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collabor...
E-bog
619,55 DKK
Forlag
Elsevier Science
Udgivet
19 december 2005
Længde
458 sider
Genrer
PHVN
Sprog
English
Format
pdf
Beskyttelse
LCP
ISBN
9780080461878
Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "e;regional"e; control is exerted by natural selection (essentially negative or purifying selection). A "e;neo-selectionist"e; model is proposed for genome evolution.* Summarizes the existing knowledge on genome organization and evolution in a self-containedbook* Discusses important open problem, without refraining from criticism wheneverappropriate