Structure and Function of GPCRs (e-bog) af -
Lebon, Guillaume (redaktør)

Structure and Function of GPCRs e-bog

2190,77 DKK (inkl. moms 2738,46 DKK)
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that ...
E-bog 2190,77 DKK
Forfattere Lebon, Guillaume (redaktør)
Forlag Springer
Udgivet 1 august 2019
Genrer PNB
Sprog English
Format pdf
Beskyttelse LCP
ISBN 9783030245917
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.